We begin this article by delineating the explanatory gaps left by prevailing gene‐focused approaches in our understanding of phenotype determination, inheritance, and the origin of novel traits. We aim not to diminish the value of these approaches but to highlight where their implementation, despite best efforts, has encountered persistent limitations. We then discuss how each of these explanatory gaps can be addressed by expanding research foci to take into accountbiological agency—the capacity of living systems at various levels to participate in (...) their own development, maintenance, and function by regulating their structures and activities in response to conditions they encounter. Here we aim to define formally what agency and agents are and—just as importantly—what they are not, emphasizing that agency is an empirical property connoting neither intention nor consciousness. Lastly, we discuss how incorporating agency helps to bridge explanatory gaps left by conventional approaches, highlight scientific fields in which implicit agency approaches are already proving valuable, and assess the opportunities and challenges of more systematically incorporating biological agency into research programs. (shrink)

Ecological developmental biology considers the phenotype as actively produced through an environmentally informed process of individual development, rather than predetermined by the genotype. Accordingly, the genotype is viewed as one among many interactants that contribute formative elements; it is understood to do so no differently from the way other organism-internal and environmental resources do. Although the EcoDevo approach is evidently particularly apt to inform approaches to human development, which mostly takes shape in rich cultural environments, it is remarkable that, at (...) least within some highly influential circles of the linguistic sciences, the study of many distinctive human cognitive traits including language remains strongly anchored to a preformationist stance. This article brings an EcoDevo approach to the biologically focused study of language to argue that an aspect of language design commonly assumed to be “blueprinted,” namely, the lexicon-syntax interface, may instead be explained as a plastic effect of ongoing developmental processes in the mind of the child, in which designated aspects of the environment fulfill a key constructive role. (shrink)

The aim of this article is to describe and analyze the undergraduate Social Foundations course I taught at an urban, inclusive university that attempted to provide students with, among other things, a forum for them to develop both a self-confident personal voice and a view of self as potential change agent of schools. In brief, with what I term pedagogical scaffolding, including the use of key essential questions and double-entry journals, undergraduate students develop personal philosophy statements that are coherent, thoughtful, (...) and self-confident and that demonstrate a sense of personal efficacy in the context of urban public schooling. Excerpts from student papers serve as evidence demonstrating that over the course of the semester students became increasingly secure while responding to academic text, in formulating clear and strong positions on education issues and, perhaps most important, in their commitments and abilities to participate in the reform of urban schools for all children. (shrink)

(2008). Charting “Unexplored Territory” in the Social Foundations: Pedagogical Practice in Urban Teacher Education. Educational Studies: Vol. 43, No. 3, pp. 229-245.

According to the dominant historiographical narrative, the social reconstructionists were a homogeneous group with a shared social, political, economic, and educational agenda. However, the pages of the journal The Social Frontier are replete with evidence that they were not in agreement on significant issues, especially when it came to the proper role of teachers in reform efforts. In fact, a close look reveals that the social reconstructionists presented multiple, overlapping, and often conflicting theories and strategies to advance the reconstruction of (...) society, while explicating different roles for teachers therein. When teachers are placed at the center of the investigation, their factionalism, which has been discussed previously by C.A. Bowers and James Giarelli in their studies of the journal, is conspicuously apparent. Analysis of the different conceptions of teachers presented in The Social Frontier (subsequently titled Frontiers of Democracy) reveals that collectively, the social reconstructionists engaged in “more than one struggle”; and individually, they held views that were influenced by personal priorities and responses to the Depression, the spread of Communism and Fascism, the start of war in Europe and Asia, and, eventually, the involvement of the United States in World War II. (shrink)

El objetivo de este trabajo es recoger de forma sistemática las principales reflexiones en torno al tema de Dios y la religión en la obra de Javier Muguerza. Con este esbozo cordial de filosofía de la religión se muestra la evolución en el pensamiento de Muguerza desde una filosofía analítica de la religión —preocupada por esclarecer el análisis lógico del lenguaje religioso y la dimensión racional de la creencia religiosa— a una filosofía práctica de la religión —centrada en las condiciones (...) de posibilidad del diálogo entre creyentes y no creyentes y en la reflexión conjunta sobre valores compartidos como la esperanza—. Por último, se defiende la tesis de que las contribuciones de Muguerza en este campo constituyen un claro ejemplo de filosofía de la religión realizada desde el respeto de la increencia. (shrink)

Este artículo continúa la investigación iniciada en «Los trasmundos del joven Ortega (1902-1914)». En esta ocasión, reconstruiré algunas ideas en torno a la religión y Dios presentes en los años correspondientes a la primera navegación de Ortega. El objetivo es superar las interpretaciones reduccionistas que rápidamente identifican a Ortega como una persona reacia a la religión. En primer lugar, recuperaré una categoría clave de la primera navegación, “la altura de los tiempos”, para mostrar cómo Ortega sitúa la religión entre otras (...) formas superiores de la cultura que considera que deben avanzar. En segundo lugar, analizaré aquellos aspectos que harían una religión indigna de la altura de los tiempos y que motivan el ansia de reforma religiosa. Por último, en tercer lugar, dilucidaré la segunda concepción orteguiana de Dios compatible con la propuesta de una “nueva” religión. (shrink)

Towards Post-Modern Trade Relations? A Review of Dennis Patterson and Ari Afilalo, The New Global Trading Order: The Evolving State and the Future of Trade.

Charles Taylor es comúnmente identificado como uno de los padres fundadores del comunitarismo teórico, pero tal identificación no da cuenta de la amplitud del pensamiento del filósofo canadiense. A través de este trabajo de investigación pretendemos articular la filosofía de Taylor partiendo del proyecto filosófico que explícitamente inicia en sus primeros trabajos, a saber, la configuración de una antropología filosófica, a través de la cual abordaremos los grandes temas que han ocupado su vida -ética, política y religión- en la puesta (...) en marcha de una filosofía con intenciones puramente prácticas.Charles Taylor is commonly identified as one of the founding fathers of theoretical communitarianism, but such identification does not realize the extent of his thinking. Through this research, we try to articulate the Taylor's philosophy from his philosophical project, that he explicitly started in his early work, namely, the configuration of a philosophical anthropology, through which we will address the major issues that have occupied his life - ethics, politics and religion- in the implementation of a philosophy with purely practical intentions. (shrink)

Taylor analiza la investigación trascendental como el método propio de la filosofía en una serie de artículos tempranos. El objetivo de este artículo es doble. En primer lugar, queremos acercar al lector a las bases filosóficas del pensamiento de Taylor, exponiendo el descubrimiento y los análisis de Taylor sobre la investigación trascendental. En segundo lugar, queremos mostrar la necesidad de atender a la metodología y a las fases de esta investigación trascendental para la correcta interpretación e identificación de la filosofía (...) de Taylor.Taylor analyzes transcendental investigation as the proper method of philosophy in a serie of early articles. The purpose of this article is double. First, we want to bring the reader closer to the philosophical foundations of Taylor's thought, exposing Taylor's discovery and analysis of transcendental investigation. Second, we want to show the need to attend to the methodology and phases of this transcendental investigation in order to achieve the correct interpretation and identification of Taylor's philosophy. (shrink)

La fenomenología de la religión es una de las ciencias de las religiones surgida en el siglo XIX. Tras una época dorada, las dificultades epistemológicas y los debates suscitados en torno al estatuto del saber la abocaron a una profunda crisis interna. En la actualidad, existen dos formas de entender la fenomenología de la religión: la primera, como historia comparada de las religiones, centrada en la descripción y clasificación de los fenómenos religiosos; la segunda, como fenomenología hermenéutica, centrada en la (...) comprensión del fenómeno religioso. Ambas corrientes constituyen dos visiones divergentes de la fenomenología de la religión. Sin embargo, podrían concebirse como dos fases fenomenológicas convergentes que apuntan a la consolidación de una antropología filosófica de la religión. En este artículo, analizamos el objetivo, los principales representantes, las dificultades epistemológicas y los logros de cada una de estas for-mas de comprender la fenomenología de la religión y su posible conjugación en la configuración de una filosofía fenomenológica de la religión.The phenomenology of religion is one of the sciences of religions emerged in the 19th century. After a golden age, the epistemological difficulties, and the debates about the status of knowledge led to a deep internal crisis. At present, there are two ways of understanding the phenomenology of religion: the first, as a com-parative history of religions, focused on description and classification of religious phenomena; the second, as a hermeneutical phenomenology, focused on the understanding of religious phenomena. Both currents constitute two divergent views of phenomenology of religion. However, they can be conceived as two convergent phenomenological phases that point to the consoli-dation of a philosophical anthropology of religion. In this paper, we analyze the goal, main representatives, epistemological difficulties and achievements of each of these ways of understanding the phenomenology of religion and its possible conjugation in the configuration of a phenomenological philosophy of religion. (shrink)

According to logical theories of meaning, a meaning of an expression can be formalized and encoded in truth conditions. Vagueness of the language and individual differences between people are a challenge to incorporate into the meaning representations. In this paper, we propose a new approach to study truth-conditional representations of vague concepts. For a case study, we selected two natural language quantifiers most and more than half. We conducted two online experiments, each with 90 native English speakers. In the first (...) experiment, we tested between-subjects variability in meaning representations. In the second experiment, we tested the stability of meaning representations over time by testing the same group of participants in two experimental sessions. In both experiments, participants performed the verification task. They verified a sentence with a quantifier (e.g., “Most of the gleerbs are feezda.”) based on the numerical information provided in the second sentence, (e.g., “60% of the gleerbs are feezda”). To investigate between-subject and within-subject differences in meaning representations, we proposed an extended version of the Diffusion Decision Model with two parameters capturing truth conditions and vagueness. We fit the model to responses and reaction times data. In the first experiment, we found substantial between-subject differences in representations of most as reflected by the variability in the truth conditions. Moreover, we found that the verification of most is proportion-dependent as reflected in the reaction time effect and model parameter. In the second experiment, we showed that quantifier representations are stable over time as reflected in stable model parameters across two experimental sessions. These findings challenge semantic theories that assume the truth-conditional equivalence of most and more than half and contribute to the representational theory of vague concepts. The current study presents a promising approach to study semantic representations, which can have a wide application in experimental linguistics. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

This article explores gender inequities and sexual double standards in teens’ digital image exchange, drawing on a UK qualitative research project on youth ‘sexting’. We develop a critique of ‘postfeminist’ media cultures, suggesting teen ‘sexting’ presents specific age and gender related contradictions: teen girls are called upon to produce particular forms of ‘sexy’ self display, yet face legal repercussions, moral condemnation and ‘slut shaming’ when they do so. We examine the production/circulation of gendered value and sexual morality via teens’ discussions (...) of activities on Facebook and Blackberry. For instance, some boys accumulated ‘ratings’ by possessing and exchanging images of girls’ breasts, which operated as a form of currency and value. Girls, in contrast, largely discussed the taking, sharing or posting of such images as risky, potentially inciting blame and shame around sexual reputation (e.g. being called ‘slut’, ‘slag’ or ‘sket’). The daily negotiations of these new digitally mediated, heterosexualised, classed and raced norms of performing teen feminine and masculine desirability are considered. (shrink)

Vivendo os momentos contemporâneos da sociedade, da ciência, da tecnologia, da virtualidade e do quadro de giz; me ponho como uma sintomatologista desses tempos. Para isso, eventualmente, me desnudo do ser professora, para, assim, poder olhar o que não vejo quando estou nas vestes dessa identidade. Os sintomas fazem com que escreva e trace muitas linhas para transitar nesse cosmo da �didática no currículo�. Algumas dessas linhas são lisas, sinuosas, umas ainda não ditas, outras ainda têm que ser esfaceladas, porém (...) elas estão sendo experimentadas com as forças da vida. Ponho-me a escrever e a estudar as questões de didática e de currículo, fazendo interlocuções com outras áreas do conhecimento como a filosofia, a história da ciência, a história e a arte. É claro que não pretendo esgotar questões dessa temática nem que o quisesse, pois são estudos de muitas vertentes conceituais. O leitor vai encontrar duas forças que produzem e produziram as didáticas: as vertigens da modernidade e as da pós-modernidade. Essas forças vertiginosas traçaram territórios diferenciados nas propostas de currículos e de planejamentos. O que quero e faço são bricolagens teóricas para encaminhar algumas teses e descrições que trago a este ensaio. (shrink)

Objectives To analyse the perspective of clinical research stakeholders concerning post-trial access to study medication. Methods Questionnaires and informed consents were sent through e-mail to 599 ethics committee (EC) members, 290 clinical investigators (HIV/AIDS and Diabetes) and 53 sponsors in Brazil. Investigators were also asked to submit the questionnaire to their research patients. Two reminders were sent to participants. Results The response rate was 21%, 20% and 45% in EC, investigators and sponsors’ groups, respectively. 54 patients answered the questionnaire through (...) their doctors. The least informative item in the consent form was how to obtain the study medication after trial. If a benefit were demonstrated in the study, 60% of research participants and 35% of EC answered that all patients should continue receiving study medication after trial; 43% of investigators believed the medication should be given to participants, and 40% to subjects who participated and benefited from treatment. For 50% of the sponsors, study medication should be assured to participants who had benefited from treatment. The majority of responders answered that medication should be provided free by sponsors; investigators and sponsors believed the medication should be kept until available in the public health sector; EC members said that the patient should keep the benefit; patients answered that benefits should be assured for life. Conclusions Due to the study limitations, the results cannot be generalised; however, the data can contribute to discussion of this complex topic through analysing the views of stakeholders in clinical research in Brazil. (shrink)

El artículo reconstruye los intereses lectores y de instrucción obrera, y también los textos escritos por los obreros y obreras a través de Hoja Obrera, periódico de publicación semanal, el cual pertenecía a la Sociedad de Trabajadores, en el período comprendido entre 1909 y 1912. De tal manera, que detalla cuáles fueron los escritores y escritoras leídos, qué textos leyeron, cuáles fueron sus preocupaciones por la instrucción obrera y la lectura, así como quiénes escribían y sobre qué escribían. La metodología (...) se basó en la profundización de Hoja Obrera, entre el 17 de octubre de 1909 y el 8 de abril de 1912, con un total de 94 ejemplares analizados. Se concluye tres aspectos fundamentales: primero, la importancia brindada por los obreros y obreras a la instrucción y a la lectura como medio para fomentar su formación intelectual y poder comprender las condiciones sociales y culturales de la sociedad costarricense; segundo, la influencia de escritores como Émile Zola, Joaquín Dicenta, Victor Hugo, Lev Tolstói, Félix Matos Bernier, entre otros, en el entendimiento de las relaciones humanas; tercero, el aporte de la escritura como una forma de denuncia de estas condiciones, principalmente a través de la poesía como medio de expresión artístico. (shrink)

Este artigo investiga a questão do prazer no díalogo Filebo de Platão, com ênfasenas contribuições de Freud sobre o mesmo tema.

Após conhecer um pouco a Tanatologia e a Escatologia, surgiu a ideia de analisar a obra “Morte e vida Severina”, de João Cabral de Melo Neto, e os diferentes aspectos da morte e da vida. Estudiosos que escreveram sobre a situação humana e a contingência da morte foram consultados para um embasamento teórico consistente. O Catecismo da Igreja Católica e a Bíblia Sagrada foram usados também. Após introdução, o artigo apresenta a análise do poema detalhando os diferentes meandros em que (...) figuram a morte. Além do embasamento teórico, há um cotejo entre o poema e as teorias. Constam, ainda, considerações a respeito da situação humana que, apesar de professar uma fé, ora torna-se objeto, ora sujeito do que lhe é inusitado. (shrink)

A presente pesquisa realiza um estudo de caso de uma rádio transmitida por meio do aplicativo WhatsApp e suas dinâmicas interativas em páginas em redes sociais online. Entre os objetivos deste estudo de inspiração etnográfica de uma rádio segmentada estão a descrição e análise dos processos de transmissão, circulação da produção de textos audioverbovisuais, modelo de negócio e interação com os ouvintes usuários do aplicativo. Pretende-se compreender possíveis experiências de pessoas comuns em ambientes digitais que provocam tensões entre os modos (...) de fazer rádio, as tecnologias digitais, a visibilidade e o suposto empoderamento do ouvinte. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Este ensaio pretende explorar a noçãoheideggeriana de angústia existencial comosuporte epistêmico da concepção psicanalítica depsicopatologia fundamental. Nessa medida oestudo apontará, através do conceito de angústia,alguns aspectos que unem filosofia e psicanálise.

Estes apontamentos são resultado de reflexões sobre experiências vividas por mim e minha filhas, após 14 anos nas terras brasileiras, refletidas na música de Renato Braz. Há muito por falar sobre as marcas tatuadas em nossas peles, memórias, olhos, cheiros, toques, no entanto, tentarei narrar algumas que nos marcaram e marcam como corpo que não pertence a este lugar. Experiências divididas com ela que chagara ao Brasil com apenas 6 meses de vida, onde a todo o momento tínhamos e temos (...) que responder à pergunta: De onde vocês são? Apesar de narradas nas “primeiras pessoas”, trazem, também, à tona o que muitas e muitos de países africanos, de pele escura, vivenciam enquanto não brasileiras/os, carimbadas/os na pele e nos sotaques do não “Norte Global”. Salientar que são apontamentos sobre nossas experiências, enquanto estrangeiras não europeias e não norte americanas. (shrink)